Antiviral Test

About Our Biosafety Laboratory
In vitro Drug Efficacy Evaluation
Antiviral TestAntimicrobial Test
In vivo Drug Dfficacy Evaluation
Virus Infection ModelBacterial Infection ModelFungal Infection Model

For antiviral drug screening, we provide Virus Titer/Load Tests using techniques like plaque assays,CPE, cytopathic effect (CPE)or qPCR to accurately measure virus amountsviral loadsin samples. This helps evaluate how well a drug reduces the virus population. Neutralization Assays are also available to determine the ability of drugs/vaccines to neutralize virus infectivity, providing insights into their mechanism of action.


● IC50 Assay

IC50 (Half Maximal Inhibitory Concentration) determination is a key method in evaluating the in vitro inhibitory effect of drugs on pathogens. By measuring the concentration of a drug that inhibits 50% of the biological activity of a pathogen, we can precisely assess its potency. This assay helps in quickly screening a large number of candidate drugs to identify those with potential antibacterial, antiviral, or antifungal properties.


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● Virus Titer/Load Test

Cytopathic effect (CPE) observation and plaque assays are common methods for detecting virus titer. Viruses infecting susceptible cells in culture cause characteristic changes. Observing these changes at different time points can estimate the virus titer. These methods are simple and intuitive, providing valuable information about virus replication and the effect of antiviral drugs in vitro. 


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qPCR detection is widely used in determining virus load, demonstrating high levels of accuracy and reproducibility for evaluating the effectiveness of antiviral drugs, enabling precise measurement of virus population reduction in vitro, and providing crucial data for drug development and optimization.


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Viral load in vaginal tissue in HSV-2 infection model


● Neutralization Assay

Neutralization assays measure the ability of antibodies or drugs to neutralize the infectivity of a pathogen. For viruses, this often involves mixing the virus with a test substance (such as a potential antiviral drug or antibody) and then assessing whether the virus can still infect host cells. This assay helps in understanding the mechanism of action of drugs and their potential to block pathogen entry into cells.


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Neutralizing Serum Hemagglutination Inhibition Assay for Influenza Vaccine


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