Heart Failure Models and Efficacy Services

Heart failure refers to the condition in which the heart is functionally impaired and fails to maintain an adequate cardiac output to support the body's normal physiological activities. Both in mouse models and in the clinic, heart failure can be diagnosed based on left ventricular ejection fraction (LVEF). GemPharmatech has developed several heart failure models which exhibit reduced ejection fraction (HFrEF), including the ischemic heart failure model (LAD) and pressure-overload heart failure model (TAC). A model of heart failure with preserved ejection fraction (HFpEF), induced by HFD+L-NAME, is also available.

Left anterior descending artery (LAD) ligation model

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