Hemophilia Models

Autoimmune Disease Models
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Wild Mouse 750
Wild Mouse 750
Rare Disease Mouse Models
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Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765

Hemophilia A is caused by a mutation in the F8 (factor VIII) gene, while hemophilia B is due to a mutation in the F9 (factor IX) gene. In patients with these conditions, the activities of factor VIII or factor IX in the blood plasma are significantly reduced, leading to spontaneous or post-traumatic bleeding. The global incidence of hemophilia A and B is estimated to be approximately 1 in 5000 and 1 in 30,000 newborns, respectively. Consequently, it is anticipated that the global number of individuals with hemophilia may exceed 1.1 million.


● Genetically Engineered Hemophilia Mouse Models

Strain No.
 Strain Name Strain Type Description
T013686 F9-KO Knockout F9-KO hemizygous male and homozygous female mice display no F9 expression and impaired blood coagulation capacity.
T004727 B6-F8-KO Knockout F8-KO hemizygous male and homozygous female mice display reduced FVIII activity (~3% compared to wildtype) and impaired blood coagulation, which can be partially attenuated by administration of recombinant FVIII