T-Cell Engagers

Autoimmune Disease Models
Autoimmune Nephropathy ModelsAsthma ModelsSystemic Lupus Erythematosus (SLE) ModelsSjögren's Syndrome ModelsAutoimmune Dermatoses Models Neuroimmune Disease ModelsInflammatory Bowel Disease ModelsRheumatoid Arthritis ModelsImmune Reconstitution Autoimmune Disease Models
Metabolic Disease Mouse Models
Obesity ModelsDiabetes ModelsMASH ModelsOsteoporosis ModelsHyperuricemia Models
Wild Mouse 750
Wild Mouse 750
Rare Disease Mouse Models
Autosomal Dominant Polycystic Kidney Disease (ADPKD)Progressive Muscular Dystrophy ModelsHemophilia A Models
Neurological Disease Mouse Models
Alzheimer's Disease (AD) ModelsHumanized Alzheimer's Disease (AD) ModelsParkinson's Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) ModelsPain Mouse ModelsDuchenne Muscular Dystrophy (DMD) Models
Oncology Mouse Models
Human Xenograft ModelsDrug ResistanceT-Cell EngagersHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models
Cardiovascular Disease Mouse Models
Heart Failure ModelsHypertension ModelsAtherosclerosis ModelsAdvanced Cardiovascular and Metabolic Complication ModelsHyperlipidemia ModelsHypertropic Cardiomyopathy ModelsStroke ModelsThrombosis Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765

T-cell engagers (TCEs) are an emerging class of immunotherapies in oncology that redirect a patient’s own T cells to recognize and kill tumor cells by simultaneously binding CD3 on T cells and a tumor-specific antigen. Unique challenges in TCE preclinical development exist due to their requirement for a functional human immune system and potential adverse effects such as cytokine release syndrome. This necessitates the use of specialized preclinical research models and human cells that accurately recapitulate human immune-tumor interactions.


GemPharmatech addresses these needs with a broad portfolio of genetically engineered mouse models and immunodeficient strains, including humanized NCG and Next-Gen NCG stains, to support CD34+ or PBMC-engrafted systems. GemPharmatech also offers preclinical services such as in vivo efficacy, PK/PD, and toxicity studies to support your development of the next-generation T-cell engagers.


Need help with your T-cell engager study? Contact us and let our team of experts help you.


Strain No.
 Strain Name Strain Type Description
T053483 BALB/c-hCD3EDG KI Expresses human CD3 delta, epsilon and gamma polypeptides on T-cell surface
T001550 BALB/c-hCD3E Transgenic Expresses human CD3 epsilon polypeptide on T-cell surface