Transthyretin Amyloidosis (ATTR) Models

Autoimmune Disease Models
Autoimmune Nephropathy ModelsAsthma ModelsSystemic Lupus Erythematosus (SLE) ModelsSjögren's Syndrome ModelsAutoimmune Dermatoses Models Neuroimmune Disease ModelsInflammatory Bowel Disease ModelsRheumatoid Arthritis ModelsImmune Reconstitution Autoimmune Disease Models
Metabolic Disease Mouse Models
Obesity ModelsDiabetes ModelsMASH ModelsOsteoporosis ModelsHyperuricemia Models
Wild Mouse 750
Wild Mouse 750
Rare Disease Mouse Models
Autosomal Dominant Polycystic Kidney Disease (ADPKD)Progressive Muscular Dystrophy ModelsHemophilia A Models
Neurological Disease Mouse Models
Alzheimer's Disease (AD) ModelsHumanized Alzheimer's Disease (AD) ModelsParkinson's Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) ModelsPain Mouse ModelsDuchenne Muscular Dystrophy (DMD) Models
Oncology Mouse Models
Human Xenograft ModelsDrug ResistanceT-Cell EngagersHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models
Cardiovascular Disease Mouse Models
Heart Failure ModelsHypertension ModelsAtherosclerosis ModelsAdvanced Cardiovascular and Metabolic Complication ModelsHyperlipidemia ModelsHypertropic Cardiomyopathy ModelsStroke ModelsThrombosis Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
Wild Mouse 765
Wild Mouse 765

Transthyretin amyloidosis (ATTR) is a rare disease characterized by the abnormal accumulation of amyloid deposits made up of misfolded transthyretin (TTR) proteins in various organs, including the retina, vitreous, kidneys, and brain. Two prominent subtypes of ATTR are transthyretin amyloid polyradiculoneuropathy (ATTR-PN) and transthyretin amyloid cardiomyopathy (ATTR-CM).

GemPharmatech has developed three mouse models by gene-editing technology. These models can be utilized for studying ATTR and evaluating the in vivo efficacy of human TTR-targeted gene and other nucleic acid-based therapies.


Strain No.
 Strain Name Strain Type Description
T059956 B6-hTTR V30M Tg mTtr-KO Transgenic Mice were developed using gene editing technology to transfer the human TTR gene with V30M mutation by transgenic method on the basis of knockout of mouse Ttr gene. Human TTR protein expression can be detected in mouse serum, while mouse TTR protein is not expressed.
T059897 B6-hTTR-V30M Transgenic The human TTR gene with V30M mutation were transferred into mouse genome to generate B6-hTTR V30M Tg mouse model. Human TTR protein expression can be detected in the serum of mice at 8 weeks of age.
T055186 B6-hTTR KI The coding region and regulatory sequences of the murine TTR gene were replaced with the corresponding human gene fragments to generate B6-hTTR mouse model. Human TTR protein expression can be detected in the serum of mice at 5 months of age.