Lupus Nephritis

Autoimmune Nephropathy Models and Efficacy Services
IgA NephropathyC3 GlomerulonephritisLupus NephritisMembranous Nphropathy
Asthma Models and Efficacy Services
HDM induced asthma modelsOVA inudced asthma models
Systemic Lupus Erythematosus (SLE) Models and Efficacy Services
Spontaneous SLE ModelsInduction SLE ModelsImmune Reconstitution SLE Models
Sjögren's Syndrome Models and Efficacy Services
Salivary Gland Protein Induced Sjögren's Syndrome Mouse ModelSTING Agonist Induced Sjögren’s Syndrome Mouse Model
Neuroimmune Diseases Models and Efficacy Services
Multiple Sclerosis (MS) ModelsMyasthenia Gravis (MG) Models
Autoimmune Dermatoses Models and Efficacy Services
Psoriasis ModelsAtopic DermatitisAlopecia Areata (AA)Vitiligo ModelsSclerodermaUrticaria
Inflammatory Bowel Disease (IBD) Models and Efficacy Services
DSS Induced IBD ModelAdaptive T cell Transfer IBD ModelImmune Reconstitution IBD ModelAnti-CD40 Induced Colitis Models
Rheumatoid Arthritis (RA) Models and Efficacy Services
Collagen Induced Arthritis ModelCollagen Antibody Induced Arthritis ModelImmune Reconstitution Arthritis ModelmBSA induced Induced DTHA Model
Immune Reconstitution Autoimmune Disease Models and Efficacy Services
SLEIBDArthritisMyasthenia GravisPassive Cutaneous AnaphylaxisPassive Systemic Anaphylaxis (PSA)

Lupus Nephritis is a serious kidney complication of systemic lupus erythematosus (SLE), an autoimmune disease. It occurs when autoantibodies form immune complexes that deposit in the kidneys, causing inflammation and damage to renal structures, particularly the glomeruli.


To aid with your preclinical studies, GemPharmatech has developed and validated a spontaneous model of lupus nephritis by overexpressing human B-cell activating factor (BAFF) in a C57BL/6J mouse.


 

C57BL6/J-hBAFF, a spontaneous lupus nephritis mouse model


The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion. BAFF expression is closely linked with lupus nephritis and is enhanced by genetic alterations and viral infections. In C57BL6/J-hBAFF mouse, the human BAFF was sustained in high level and lupus nephritis is developed spontaneously.


10.jpeg

Fig 1. C57BL6/J-hBAFF mice present with a spontaneous lupus nephritis phenotype. A: the model strategy of C57BL6/J-hBAFF; B: high levels of serum anti-dsDNA in C57BL6/J-hBAFF mouse were observed from 6 week to 34 week; # refers to animal ID; C:, kidney biopsy (×200) shows glomerulus enlargement, immune complex deposition, segmental fibrinoid necrosis (↑), crescent formation (↑), peripheral renal tubular atrophy (↑), lymphocytes infiltration (↑), capsule adhesion (↑), and hyaline thrombus (↑); D: the deposition of immune complex in C57BL6/J-hBAFF kidney; E: The efficacy study of anti-hBAFF (Belimumab) on C57BL6/J-hBAFF lupus nephritis model. Significant remission was observed by the treatment of Belimumab accompanied with the decrease of UACR, serum anti-dsDNA and NIH scores. Data presented as mean ± SEM. *P<0.05，**P<0.01；***P<0.001.

TALK WITH OUR EXPERTS

GemPharmatech is committed to protecting and respecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please click below to say how you would like us to contact you:

In order to provide you with the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please click the checkbox below.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.