Salivary Gland Protein Induced Sjögren's Syndrome Mouse Model
At GemPharmatech, we have established several models of Sjogren's Syndrome. The Sjogren's syndrome model induced by salivary gland proteins is a classic animal model used for evaluating the preclinical efficacy of drugs for treating Sjogren's syndrome.
Fig.1 Salivary gland protein-induced mouse SS model
The Salivary gland protein induced model strategy is shown in Fig.1A. After immunizing Balb/c mice for 35 or 63 days, the salivary flow rate of the mice in the model group significantly decreased (Fig.1B). The level of anti-dsDNA in the serum increased in model group (Fig.1C). The results of HE pathological staining of the salivary glands showed that inflammatory cells, including CD3+ T cells infiltration into the salivary gland tissues in the model group (Fig.1D,E).