Passive Cutaneous Anaphylaxis

Passive Cutaneous Anaphylaxis (PCA) model induced in HuHSC-NCG-M mice

Human hematopoietic stem cells(HSCs) were infused into NCG-M (strain No.T036669) immunodeficient mice , to reconstitute the human immune system (HIS). The HIS reconstituted NCG-M mice were administrated with NP-specific IgE and re-challenged with NP-KLH to establish PCA model.

Fig.1 Anti-NP IgE-induced PCA in HSC-NCG-M mouse model

PCA model strategy is shown in Fig. 1A. 0.75 h post NP-KLH administration, mice in modeling group exhibited dye leakage in dorsal skin (Fig.2B-C). Data were presented by mean ± SEM. **P<0.01.

TALK WITH OUR EXPERTS

*

STATE/PROVINCE

*

How did you hear about us?

Search Engine Social Media Email Colleague Referral Conference Webinar Other

GemPharmatech is committed to protecting and respecting your privacy, and we'll only use your personal information to administer your account and to provide the products and services you requested from us. From time to time, we would like to contact you about our products and services, as well as other content that may be of interest to you. If you consent to us contacting you for this purpose, please click below to say how you would like us to contact you:

I agree to receive other communications from GemPharmatech.

In order to provide you with the content requested, we need to store and process your personal data. If you consent to us storing your personal data for this purpose, please click the checkbox below.

I agree to allow GemPharmatech to store and process my personal data.

You can unsubscribe from these communications at any time. For more information on how to unsubscribe, our privacy practices, and how we are committed to protecting and respecting your privacy, please review our Privacy Policy.