Diabetic Nephropathy

Diabetic nephropathy is one of the most common complications of diabetes, affecting 20-50% of diabetic patients. The pathogenesis of diabetic nephropathy is complex, with metabolic disorders (chronic hyperglycemia) and systemic hypertension being key factors in promoting the progression of renal disease. GemPharmatech has developed two kinds of progressive diabetic kidney disease mouse models based on BKS-Lepr^-/- using gene editing techniques to knock out the Nos3 gene or using virus transduction to overexpress Renin, which induces systemic hypertension and endothelial injury, accelerating renal lesions in BKS-Lepr^-/- mice.

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